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Estimation of the Configurational Stability of Chiral Organometallic Reagents
Author(s) -
Hoffmann Reinhard W.,
Lanz Joachim,
Metternich Rainer,
Tarara Gerhard,
Hoppe Dieter
Publication year - 1987
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198711451
Subject(s) - reagent , racemization , aldehyde , chemistry , organic chemistry , combinatorial chemistry , catalysis
The relative rates of racemization of chiral organometallic reagents can be obtained by reaction of the racemic reagent with a chiral aldehyde–in one experiment, racemic, in the other, enantiomerically pure [Eq. (a)]. The greater the configurational stability of the reagent, the larger the difference in the product ratios for the racemic and the enantiomerically pure aldehyde.