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Lactosylceramides with Unsaturated Fatty Acids—Synthesis and Use in the Generation of Bilayer Membranes
Author(s) -
Schmidt Richard R.,
Bär Thomas,
Apell HansJuergen
Publication year - 1987
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198707931
Subject(s) - membrane , bilayer , phosphatidylcholine , chemistry , materials science , phospholipid , biochemistry
The lactosylceramides 1–4 form bilayer membranes having longevities of several hours as well as electrical capacities that are appreciably larger than those of phosphatidylcholine membranes. Important for the preparation of the planar bilayers is the use of chemically pure glycosphingolipids. Compounds 1–4 were synthesized in only a few steps in good yields.