Reduction of 2‐Enoates and Alkanoates with Carbon Monoxide or Formate, Viologens, and  Clostridium thermoaceticum  to Saturated Acids and Unsaturated and Saturated Alcohols | Zendy

Simon Helmut | Zendy; White Hiltrud | Zendy; Lebertz Herbert | Zendy; Thanos Iordanes | Zendy

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Reduction of 2‐Enoates and Alkanoates with Carbon Monoxide or Formate, Viologens, and Clostridium thermoaceticum to Saturated Acids and Unsaturated and Saturated Alcohols

Author(s) -

Simon Helmut,

White Hiltrud,

Lebertz Herbert,

Thanos Iordanes

Publication year - 1987

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198707851

Subject(s) - chemistry , formate , reagent , carbon monoxide , aqueous solution , organic chemistry , medicinal chemistry , catalysis

The biochemical system used to carry out the title reactions in aqueous solution is probably also of preparative value. The unsaturated carboxylates 1 afford the saturated analogues 2 at pH 7.5 in the presence of CO, H 2 , or HCOO ⊖ and give the alcohols 3 and 4 at pH 5.5; with the same reagents at pH 5.5, the transformation 2→3 occurs. The carboxyl groups of compounds 1 and 2 are not activated in this process as is the case in the corresponding biological reactions. R 1 , R 2 = Me, Ph, CHCHCH 3 .

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