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Regulation of the 6‐s Equilibrium Conformation of Retinal in Bacteriorhodopsin by Substitution at C‐5; 5‐Methoxy‐ and 5‐Ethylretinalbacteriorhodopsin
Author(s) -
Kölling Elisabeth,
Oesterhelt Dieter,
Hopf Henning,
Krause Norbert
Publication year - 1987
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198705801
Subject(s) - bacteriorhodopsin , substitution (logic) , chemistry , retinal , proton , stereochemistry , statement (logic) , biochemistry , physics , membrane , philosophy , quantum mechanics , linguistics , epistemology
Rotation around the C6‐C7 bond of retinal reduces the proton transport activity of bacteriorhodopsin , but does not totally suppress it. This statement summarizes the results of experiments on the effect of replacing the methyl groups at positions C‐5 and C‐13 by ethyl or methoxy groups. The synthesis of 5‐methoxyretinal is described (R, R′ = CH 3 , C 2 H 5 , OCH 3 ).