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2 H, 2 H‐COSY and 2 H, 2 H, 13 C‐RELAY NMR Experiments for the Analysis of Deuteriated Compounds
Author(s) -
Moskau Detlef,
Günther Harald
Publication year - 1987
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198701561
Subject(s) - homonuclear molecule , deuterium , chemistry , nuclear magnetic resonance spectroscopy , spectroscopy , phosphorus 31 nmr spectroscopy , analytical chemistry (journal) , physics , stereochemistry , molecule , atomic physics , chromatography , organic chemistry , quantum mechanics
Determination of the homonuclear coupling between and the correlation of 13 C nuclei via vicinal deuterium nuclei has been achieved by 2D NMR spectroscopy . [D 5 ]Pyridine was used to show that the only 0.1‐ to 0.2‐Hz 3 J ( 2 H, 2 H) values lead to significant cross signals in the COSY experiment and that the RELAY experiment is a promising alternative when 2 H, 13 C correlation and 2 H, 2 H COSY NMR spectroscopy fail owing to overlapping of signals.