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Asymmetric Synthesis of Cyclic α‐Amino Acids by the Bislactim Ether Method
Author(s) -
Schöllkopf Ulrich,
Hinrichs Rolf,
Lonsky Ralph
Publication year - 1987
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198701431
Subject(s) - ether , chemistry , enantioselective synthesis , amino acid , stereochemistry , organic chemistry , biochemistry , catalysis
Methylproline, 1a, and its cyclic homologues, 1b and 2 , have been synthesized without direct recourse to the “chiral pool.” The multistep synthesis starts from the bislactim ether 3 and the dibromides 4a,b and 5 ( a , n = 1; b , n = 2).