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Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin
Author(s) -
Kessler Horst,
Klein Mechtild,
Müller Arndt,
Wagner Klaus,
Bats Jan Willem,
Ziegler Kornelia,
Frimmer Max
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198609971
Subject(s) - somatostatin , in vitro , chemistry , biochemistry , biology , endocrinology
Constitution and conformation determine the biological activity of a peptide , as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2 . The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively.
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