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Enantiomeric Resolution by HPLC on Silica‐Gel‐Bound, Optically Active Polyamides
Author(s) -
Blaschke Gottfried,
Bröker Werner,
Fraenkel Werner
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198608301
Subject(s) - enantiomer , silica gel , optically active , high performance liquid chromatography , monomer , chemistry , resolution (logic) , chromatography , polyamide , chiral column chromatography , polymerization , adsorption , organic chemistry , polymer , artificial intelligence , computer science
Pressure‐stable adsorbents for the direct HPLC separation of numerous racemic drugs are obtained by polymerization of the monomers 1 in the presence of acryloyl‐ or diolsubstituted silica gel. Optically active poly‐acrylamides and polymethacrylamides that are not bound to silica gel have already proven useful in low‐pressure chromatography.