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A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture)
Author(s) -
Brown Michael S.,
Goldstein Joseph L.
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198605833
Subject(s) - endocytosis , ldl receptor , receptor , cholesterol , arteriosclerosis , receptor mediated endocytosis , familial hypercholesterolemia , biology , liver x receptor , microbiology and biotechnology , endocrinology , nuclear receptor , genetics , lipoprotein , gene , transcription factor
How does the healthy organism regulate cholesterol metabolism ? The answer to this question was obtained, inter alia, by studies on patients with a genetic disease, familial hypercholesterolemia. Michael S. Brown and Joseph L. Goldstein recognized thereby the key role of the receptor for the cholesterol‐transport protein LDL. The receptor is a well‐characterized protein; studies afforded insights into endocytosis and the pathway by which the receptors enter and leave the cell. Genetic defects in the LDL receptors give rise to an accumulation of cholesterol in plasma and premature arteriosclerosis.