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Direct Aminolysis of Unactivated Esters at High‐Pressure
Author(s) -
Matsumoto Kiyoshi,
Hashimoto Shiro,
Otani Shinichi
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198605651
Subject(s) - aminolysis , catalysis , chemistry , high pressure , primary (astronomy) , organic chemistry , reaction conditions , thermodynamics , physics , astronomy
The preparation of amides 3 from nonactivated esters 1 and secondary amines 2 has been achieved at 8 kbar and approximately 45°C. This reaction cannot be carried out at normal pressure without a catalyst; even the reaction with primary amines (uncatalyzed, normal pressure) requires temperatures above 200°C.