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Facile Entry to Geminally Dialkylated Chlorins
Author(s) -
Montforts FranzPeter,
Zimmermann Gottfried
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198604581
Subject(s) - geminal , pyrrole , chemistry , amide , stereochemistry , medicinal chemistry , organic chemistry
Patially reduced porphinoid pigments such as Factor I 1 and sirohydrochlorin are of great biochemical importance. It has now been possible, on model compounds, to carry out the geminal dialkylsubstitution in the saturated pyrrole rings (such as A) — this was achieved remarkably simply by Claisen rearrangement of amide acetals.