Synthesis of  N ‐(1‐Carboxy‐5‐aminopentyl)dipeptides as Inhibitors of Angiotensin Converting Enzyme | Zendy

Escher Rüdiger | Zendy; Bünning Peter | Zendy

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Synthesis of N ‐(1‐Carboxy‐5‐aminopentyl)dipeptides as Inhibitors of Angiotensin Converting Enzyme

Author(s) -

Escher Rüdiger,

Bünning Peter

Publication year - 1986

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198602771

Subject(s) - enzyme , chemistry , angiotensin converting enzyme , alkyl , renin–angiotensin system , stereochemistry , lysine , biochemistry , combinatorial chemistry , organic chemistry , amino acid , medicine , blood pressure

Excellent ligands for an affinity chromatography of angiotensin converting enzyme have been found, namely the new inhibitors of this enzyme such as 1 , R 1 , R 2 H, alkyl. They were prepared from N ε ‐Boc‐ L ‐lysine methyl ester and α;‐trifluoromethanesulfonyloxycarboxylic esters. Inhibitors of this enzyme are of pharmaceutical importance.

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