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The First Evidence of Endogenous Pyridoxyl Isoquinoline Alkaloids in Mammalian Organisms
Author(s) -
Bringmann Gerhard,
Schneider Stephan
Publication year - 1986
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198601771
Subject(s) - isoquinoline , pyridoxine , endogeny , pharmacology , vitamin b6 , chemistry , alkaloid , biochemistry , medicine , stereochemistry , vitamin
The “animal alkaloids” 1 , RH, CO 2 H, can be detected in rats after intravenous administration of therapeutically common doses of vitamin B 6 (pyridoxine) and L‐dopa. To accomplish this, it was necessary to develop a method for the analysis of extremely polar substances.