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Asymmetric Addition of a Chiral Cyclic Phosphite to a Cyclic Imine—Synthesis of Phosphonic Acid Analogues of D ‐ and L ‐Penicillamine
Author(s) -
Hoppe Inga,
Schöllkopf Ulrich,
Nieger Martin,
Egert Ernst
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198510671
Subject(s) - imine , chemistry , penicillamine , medicinal chemistry , stereochemistry , organic chemistry , catalysis
α‐Amino phosphonic acids, analogues of α‐amino carboxylic acids , are of interest because of their potential biological activity. The title reaction makes possible the preparation of (easily separated) diastereomers, which can be saponified to give penicillamine analogues (RC(CH 3 ) 2 OCH 3 ).