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Enantioselective Hydrosilylation of Prochiral 3,4‐Dihydro‐2 H ‐pyrrole Derivatives
Author(s) -
Becker Richard,
Brunner Henri,
Mahboobi Siavosh,
Wiegrebe Wolfgang
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198509951
Subject(s) - hydrosilylation , enantioselective synthesis , pyrrole , catalysis , chemistry , organic chemistry
The asymmetric synthesis of pyrrolidines can be accomplished with moderate ee values by Rh‐catalyzed hydrosilylation of dihydropyrroles such as 1 . After acylating work‐up of the silylamines 2 initially formed (≤64%), trifluoroacetamides 3 can be isolated in yields of between 80 and 90%.
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