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The First Chemical Partial Synthesis of the Nickel Complex of a Cobyrinic Acid Derivative
Author(s) -
Holze Gerhard,
Inhoffen Hans Herloff
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198508671
Subject(s) - transmetalation , nickel , cobalt , derivative (finance) , chemistry , metal ions in aqueous solution , metal , vitamin b12 , medicinal chemistry , stereochemistry , inorganic chemistry , organic chemistry , catalysis , financial economics , economics , biochemistry
The transmetalation of a vitamin B 12 building block was achieved as follows: oxidation of 1 , NCo(CN) 2 , to the seco compound, demetalation, reaction with Ni(ClO 4 ) 2 , and recyclization at 100°C to give 1, MNiClO 4 . Corrinoids of this kind, containing metal ions other than cobalt, were previously only accessible from natural metal‐free corrinods or by total synthesis.