Premium
From the Structure of Antibodies to the Diversification of the Immune Responce (Noble Lecture)
Author(s) -
Milstein Cesar
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198508161
Subject(s) - antibody , diversification (marketing strategy) , immune system , virology , microbiology and biotechnology , immunology , medicine , biology , business , marketing
The unimaginable variety of antibody structures is evidenced by the fact that an animal produces specific antibodies against bacteria, viruses, and other foreign substances, even against substances with which it has had no prior contact. How is this possible? In his lecture, on the occasion of accepting the 1984 Nobel Prize for Physiology and Medicine, Cesar Milstein describes work directed toward answering this question. These investigations have led to, among other things, the development of the hybridoma technique in collaboration with G. Köhler .