Premium
Solid Phase Synthesis (Nobel Lecture)
Author(s) -
Merrifield Robert Bruce
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198507993
Subject(s) - solid phase synthesis , peptide synthesis , chemistry , phase (matter) , combinatorial chemistry , polymer science , peptide , nanotechnology , organic chemistry , materials science , biochemistry
A solid phase as “protecting group” in peptide synthesis —this was the original idea of Bruce Merrifield , who received the 1984 Nobel Prize for Chemistry. In his lecture, he describes the development of the Merrifield synthesis. In principle, all difunctional educts that may be selectively protected at one end and activated at the other can undergo reactions on solid supports.