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Selective 1 H, 13 C‐NOE Difference Spectroscopy for the Elucidation of Structures
Author(s) -
Bigler Peter,
Kamber Matthias
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198507051
Subject(s) - heteronuclear molecule , nuclear overhauser effect , coupling constant , lactone , chemistry , spectroscopy , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , physics , particle physics , quantum mechanics
Structure elucidations are also possible for compounds with strongly overlapping 1 H‐NMR signals employing a new procedure based on the use of the heteronuclear Overhauser effect. This 1D procedure requires only relatively short measuring times, and a knowledge of the coupling constants is not necessary. The capability of the method is demonstrated on a tricyclic β‐Keto ester containing a lactone bridge.