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Enzymes as Catalysts in Synthetic Organic Chemistry [New Synthetic Methods (53)]
Author(s) -
Whitesides George M.,
Wong ChiHuey
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198506173
Subject(s) - organic synthesis , catalysis , biochemical engineering , chemistry , organic chemistry , enzyme , synthetic biology , scale (ratio) , nanotechnology , combinatorial chemistry , materials science , engineering , biology , computational biology , physics , quantum mechanics
Enzymes have great potential as catalysts for use in synthetic organic chemistry. Applications of enzymes in synthesis have so far been limited to a relatively small number of largescale hydrolytic processes used in industry, and to a large number of small‐scale syntheses of materials used in analytical procedures and in research. Changes in the technology for production of enzymes (in part attributable to improved methods from classical microbiology, and in part to the promise of genetic engineering) and for their stabilization and manipulation now make these catalysts practical for wider use in large‐scale synthetic organic chemistry. This paper reviews the status of the rapidly developing field of enzyme‐catalyzed organic synthesis, and outlines both present opportunities and probable future developments in this field.