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Total Synthesis of Ulicyclamide
Author(s) -
Schmidt Ulrich,
Gleich Peter
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198505691
Subject(s) - thiazole , isoleucine , total synthesis , organism , key (lock) , alanine , chemistry , stereochemistry , combinatorial chemistry , condensation , biology , amino acid , biochemistry , leucine , ecology , physics , genetics , thermodynamics
A cancerostatic cyclopeptide from a marine organism , which contains both thiazole as well as dihydrooxazole rings, was the first of its kind to be synthesized. A key step in the synthesis is the condensation of the thiazoles 1 and 2 (generated from ( S )‐isoleucine and ( S )‐alanine, respectively).
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