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Exhaustive tert ‐Butoxycarbonylation of Peptide Nitrogens
Author(s) -
Grehn Leif,
Ragnarsson Ulf
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198505101
Subject(s) - peptide , chemistry , amino acid , stereochemistry , nitrogen , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry
The protection of all nitrogen atoms in amino acids and peptides by the Bocgroup is easily possible using a new procedure. Model compounds were allowed to react with Boc 2 O (in excess) in the presence of 4‐dimethylaminopyridine. Examples are the reaction of Boc‐Gly‐OBzl to give 1 and Boc‐ Pro Gly‐OMe to give to 2 .The products are surprisingly stable.