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A Nucleolipid with Antiviral Acycloguanosine as Head Group—Synthesis and Liposome Formation
Author(s) -
Rosemeyer Helmut,
Ahlers Michael,
Schmidt Brigitta,
Seela Frank
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198505011
Subject(s) - liposome , stereochemistry , chemistry , covalent bond , nucleoside , molecule , nucleoside analogue , group (periodic table) , combinatorial chemistry , biochemistry , organic chemistry
Acyloquanosine—a nucleoside analogue with strong antiviral activity — was coupled covalently via a hydrolyzable spacer with a double‐chain lipid to give the amphiphilically active molecule 1 . In water, 1 forms liposomes which could function as transport form of this pharmacon.
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