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Short Synthesis of Cerebrosides
Author(s) -
Schmidt Richard R.,
Kläger Rudolf
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198500651
Subject(s) - cerebroside , chemistry , product (mathematics) , stereochemistry , combinatorial chemistry , chromatography , mathematics , biochemistry , geometry
Use of the trichloroacetimidate method for the synthesis of cerebroside has reduced the number of reaction steps and increased the yields. The key step is the reaction of the 1‐ O ‐unprotected D , L ‐ceramides with a trichloroacetimidate to give the D ‐glucocerebrosides DL ‐ 1 and DD ‐ 1 , which can be quantitatively deblocked to produce DL ‐ 2 and DD ‐ 2 (natural product).