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Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis
Author(s) -
Masamune Satoru,
Choy William,
Petersen John S.,
Sita Lawrence R.
Publication year - 1985
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198500013
Subject(s) - asymmetric induction , enantioselective synthesis , aldol reaction , context (archaeology) , organic synthesis , viewpoints , chemistry , catalysis , outcome (game theory) , combinatorial chemistry , computational chemistry , organic chemistry , mathematical economics , mathematics , physics , paleontology , acoustics , biology
This account examines double asymmetric induction from theoretical and practical viewpoints. In the context of four major organic reactions‐the aldol, Diels‐Alder, catalytic hydrogenation, and epoxidation‐it is shown that a double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants. A rule which qualitatively relates the results of these single asymmetric reactions with the outcome of the double asymmetric reaction is proposed. A powerful new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.