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Total Synthesis of Hexaacetylcelenamide A
Author(s) -
Schmidt Ulrich,
Wild Jochen
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198409911
Subject(s) - total synthesis , moiety , stereochemistry , double bond , alkaloid , chemistry , peptide synthesis , peptide , combinatorial chemistry , organic chemistry , biochemistry
The first total synthesis of a linear peptide alkaloid , namely hexaacetylcelenamide A, which occurs in Pacific sponges, has been accomplished. This synthesis concomitantly verified the configuration of the double bond in the dehydroamino acid moiety (R = COCH 3 ).