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Synthesis of the Antibiotic LL‐Z1120—Contribution to an Understanding of the 1,4‐Dioxocine System
Author(s) -
Altenbach HansJosef,
Lex Johann,
Linkenheil Dieter,
Voss Burkhard,
Vogel Emanuel
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198409661
Subject(s) - derivative (finance) , natural product , benzene , ring (chemistry) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , business , finance
Correlations between natural product synthesis and 10π‐arene chemistry are met with in the synthesis of the antibiotically active syn ‐benzene dioxide derivative 5 , which is in thermal equilibrium with the dioxocine derivative 4 . The eight membered ring in 4 is present in the twist‐boat‐chair form, whereas in 1 , COCl instead of CHO, it is almost planar.