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Structure‐ and Solvent‐Dependence in the Complexation of Lipophilic Substrates in a Water‐Soluble Azacyclophane
Author(s) -
Schneider HansJörg,
Philippi Klaus,
Pöhlmann Jürgen
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198409081
Subject(s) - titration , naphthalene , chemistry , aqueous solution , solvent , salt (chemistry) , proton nmr , methylation , computational chemistry , inorganic chemistry , stereochemistry , organic chemistry , biochemistry , gene
After methylation to the tetraammonium salt , the azacyclophane 1 can be used as a host compound, even in neutral aqueous solutions. It has sufficient methyl groups to allow accomodation of naphthalene derivatives with continuous anti ‐configuration of the chain. The complexation energies can be determined by “NMR‐shift titration”. X= ⊕ NMe 2 Cl ⊖ .