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Highly Enantioselective Homoaldol Additions with Chiral N ‐Allylureas—Application to the Synthesis of Optically Pure γ‐Lactones
Author(s) -
Roder Hanno,
Helmchen Günter,
Peters EvaMaria,
Peters Karl,
von Schnering HansGeorg
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198408981
Subject(s) - enantioselective synthesis , optically active , chemistry , organic chemistry , stereochemistry , catalysis
Numerous lactones are important pheromones, olfactories, or chiral synthetic building blocks. The enantioselective synthesis of lactones of the type 3 has now been accomplished using the readily accessible chiral allyltitanium compounds 1 and ent ‐ 1 by successive addition to aldehydes and ketones, acid hydrolysis, and oxidation.