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Synthesis of the all‐ L ‐Configurated Cyclohexadepsipeptide cyclo ‐[ L ‐Val‐ L ‐Lac] 3 by the Peoc/Acid Chloride Method
Author(s) -
Kunz Horst,
Lerchen HansGeorg
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198408081
Subject(s) - depsipeptide , ring (chemistry) , stereochemistry , chemistry , chloride , combinatorial chemistry , organic chemistry
The cyclization of linear depsipeptides is known to be especially difficult when only building blocks having the same configuration are present or when the amino acid residues are not N ‐methylated. Ring closure to give 1 was accomplished with the acid chlorides of Peoc‐protected depsipeptides, despite simultaneous occurrence of both complicating factors.