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Microbial Asymmetric Catalysis—Enantioselective Reduction of Ketones [New Synthetic Methods (45)]
Author(s) -
Sih Charles J.,
Chen ChingShih
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198405701
Subject(s) - enantioselective synthesis , substrate (aquarium) , chemistry , catalysis , reduction (mathematics) , combinatorial chemistry , organic chemistry , substrate specificity , enzyme , mathematics , biology , ecology , geometry
Microbial asymmetric reduction of ketones is a method widely used for the preparation of chiral alcohols. The present progress report deals with the basic concepts that govern enantioselectivity of enzymes and intact cells. Strategies to control the stereochemical course of microbial reductions of carbonyl compounds and the relationship of substrate structure to enantioselectivity are considered.