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Synthesis of Substituted, Partially Hydrogenated [1,2,4]Triazino[4,5‐ a ]indoles and Pyrrolo[1,2‐ d ][1,2,4]triazines
Author(s) -
Böttcher Henning,
Arzt Bernd
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198405182
Subject(s) - ring (chemistry) , benzene , cycloaddition , chemistry , reagent , diethyl azodicarboxylate , mitsunobu reaction , generalization , medicinal chemistry , combinatorial chemistry , organic chemistry , mathematics , catalysis , triphenylphosphine , mathematical analysis
A novel cycloaddition with the Mitsunobu reagent (diethyl azodicarboxylate/PPh 3 ) converts the hydroxyalkylindoles 1 into the triazinoindoles 2 . Derivatives without an annelated benzene ring can be obtained analogously. Generalization of the synthesis ought to lead to further interesting heterocycles.