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α‐Keto Esters and α‐Keto Nitriles via Ruthenium‐Catalyzed Dehydrogenation of α‐Hydroxy Esters and Cyanohydrins with tert ‐Butyl Hydroperoxide
Author(s) -
Tanaka Masato,
Kobayashi Toshiaki,
Sakakura Toshiyasu
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198405181
Subject(s) - dehydrogenation , ruthenium , catalysis , chemistry , alkyl , medicinal chemistry , organic chemistry
A new method for dehydrogenation of functionalized alcohols 1 , ZCO 2 ‐alkyl or CN, is their Ru‐catalyzed reaction with tBuOOH. The reaction proceeds under extremely mild conditions; for 1, R(E)‐PhCHCH, the double bond is not epoxidized.