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Asymmetric Synthesis of a Novel Enantiomerically Pure Prostaglandin Building Block
Author(s) -
Gais HansJoachim,
Lied Thomas,
Lukas Karl L.
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198405111
Subject(s) - block (permutation group theory) , prostaglandin , chemistry , enantioselective synthesis , combinatorial chemistry , stereochemistry , organic chemistry , mathematics , combinatorics , catalysis , biochemistry
A general route to prostaglandins is opened up by the synthesis of the chiral compound 2, R = t BuMe 2 Si, from the readily accessible keto ester 1 . Compound 2 can be linked to various side chains by means of a 1,4‐addition‐carbonyl‐olefination strategy.