Premium
Transfer of Chirality in the Addition of Chiral α‐Chloroallylboronate Esters to Aldehydes
Author(s) -
Hoffmann Reinhard W.,
Landmann Bernd
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198404371
Subject(s) - chirality (physics) , enantioselective synthesis , reagent , center (category theory) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , crystallography , catalysis , chiral symmetry , physics , particle physics , nambu–jona lasinio model , quark
The chiral integrity of an auxiliary reagent must be transferred to the new center of chirality in every enantioselective synthesis. This is achieved particularly effectively if the controlling center, as in 1 , directly influences the conformation of a cyclic transition state.