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Asymmetric Hydrogenation of α‐(Acetylamino)cinnamic Acid with a Novel Rhodium Complex; the Design of an Optimal Ligand
Author(s) -
Nagel Ulrich
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198404351
Subject(s) - rhodium , cinnamic acid , asymmetric hydrogenation , ligand (biochemistry) , chemistry , substrate (aquarium) , stereochemistry , salt (chemistry) , combinatorial chemistry , organic chemistry , medicinal chemistry , enantioselective synthesis , catalysis , biochemistry , receptor , biology , ecology
A novel, chiral bisphosphane ligand with variable N ‐substituents is contained in the Rh complex 1 . 1 (BF 4 salt) catalyzes the hydrogenation of α‐(acetylamino)cinnamic acid, even at high H 2 ‐pressure and with large amounts of substrate, in up to 99% ee . 1 is also highly propitious when bonded to carriers.