Asymmetric Hydrogenation of α‐(Acetylamino)cinnamic Acid with a Novel Rhodium Complex; the Design of an Optimal Ligand | Zendy

Nagel Ulrich | Zendy

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Asymmetric Hydrogenation of α‐(Acetylamino)cinnamic Acid with a Novel Rhodium Complex; the Design of an Optimal Ligand

Author(s) -

Nagel Ulrich

Publication year - 1984

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198404351

Subject(s) - rhodium , cinnamic acid , asymmetric hydrogenation , ligand (biochemistry) , chemistry , substrate (aquarium) , stereochemistry , salt (chemistry) , combinatorial chemistry , organic chemistry , medicinal chemistry , enantioselective synthesis , catalysis , biochemistry , receptor , biology , ecology

A novel, chiral bisphosphane ligand with variable N ‐substituents is contained in the Rh complex 1 . 1 (BF 4 salt) catalyzes the hydrogenation of α‐(acetylamino)cinnamic acid, even at high H 2 ‐pressure and with large amounts of substrate, in up to 99% ee . 1 is also highly propitious when bonded to carriers.

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