Premium
Dextran‐Linked N 6 ‐(2‐Isopentenyl)adenosine—A Polymer‐Bound Antimetabolite with a Predetermined Cleavage Position
Author(s) -
Rosemeyer Helmut,
Seela Frank
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198403851
Subject(s) - dithiothreitol , cleavage (geology) , covalent bond , chemistry , adenosine , dextran , antimetabolite , conjugate , bond cleavage , stereochemistry , nucleoside , linker , combinatorial chemistry , biochemistry , organic chemistry , catalysis , enzyme , materials science , computer science , mathematics , mathematical analysis , toxicity , fracture (geology) , composite material , operating system
The cleavage of a covalently bonded active substance from a polymeric carrier is rarely a resolvable task with sensitive active components. The modified nucleoside in 1 , linked via a special “spacer” with dextran, exhibits high antitumor activity. The SS bond can be opened reductively even with dithiothreitol.