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Enantioselective Synthesis of β‐Substituted Primary Amines; α‐Alkylation/Reductive Amination of Aldehydes via SAMP‐Hydrazones
Author(s) -
Enders Dieter,
Schubert Heinrich
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198403651
Subject(s) - reductive amination , alkylation , enantioselective synthesis , enantiomer , chemistry , amination , primary (astronomy) , organic chemistry , enantiomeric excess , combinatorial chemistry , catalysis , physics , astronomy
Either of the desired enantiomers of the β‐substituted amines 3 can be prepared in high enantiomeric purity ( ee ≥ 95%) from the aldehydes 1 . The new, generally applicable synthesis involves α‐alkylation, followed by reductive amination via the SAMP‐hydrazones 2.