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Stereoselective Total Synthesis of Chlamydocin and Dihydrochlamydocin
Author(s) -
Schmidt Ulrich,
Lieberknecht Albrecht,
Griesser Helmut,
Bartkowiak Frank
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198403181
Subject(s) - stereoselectivity , enantioselective synthesis , tetrapeptide , tartaric acid , stereochemistry , chemistry , total synthesis , in vitro , organic chemistry , biochemistry , catalysis , peptide , citric acid
The tetrapeptide chlamydocin 1 exhibits extremely high cytostatic activity in vitro. In the stereoselective synthesis of 1 , the chiral center at position 9 was obtained from natural tartaric acid, that at the α‐position by enantioselective hydrogenation from the dehydroamino acid.