Enantioselective Michael Additions with Optically Active Co  II  /Diamine Catalysts | Zendy

Brunner Henri | Zendy; Hammer Benedikt | Zendy

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Enantioselective Michael Additions with Optically Active Co II /Diamine Catalysts

Author(s) -

Brunner Henri,

Hammer Benedikt

Publication year - 1984

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198403121

Subject(s) - enantioselective synthesis , catalysis , methyl vinyl ketone , enantiomer , ketone , michael reaction , enantiomeric excess , chemistry , diamine , optically active , organic chemistry , medicinal chemistry , polymer chemistry

Optical inductions of up to 66% ee have been achieved in the Michael addition of methyl vinyl ketone to methyl 1‐oxo‐2‐indanecarboxylate to give ( R )‐ 1 . The catalyst used was Co(acac) 2 /(+)‐(nn); nn = H 2 NCPhHCPhHNH 2 . Depending upon the conditions, the ( S )‐enantiomer can also be obtained. With the complex Co(acac) 2 [()‐(nn)], ( S )‐ 1 is formed.

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