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Rotational Barriers of 4‐Aryl‐1, 4‐dihydropyridines (Ca Antagonists)
Author(s) -
Goldmann Siegfried,
Geiger Walter
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198403011
Subject(s) - alkane stereochemistry , nifedipine , chemistry , active compound , stereochemistry , aryl , calcium , organic chemistry , molecule , alkyl
Indications of the “pharmacologically active conformation” of the cardiotherapeutic 1 were obtained by 1 H‐NMR investigations on model compounds. A rapidly adjusting rotameric equilibrium apparently exists between the (preferred) synperiplanar and the antiperiplanar forms of 1 . Nifedipine 1 , R CH 3 , X NO 2 , has acquired great importance as the active component in Adalat®.
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