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A Convenient Method for the Preparation of 1‐( tert ‐Butyloxycarbonyl) pyrroles
Author(s) -
Grehn Leif,
Ragnarsson Ulf
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198402961
Subject(s) - pyrrole , catalysis , nitrogen , chemistry , organic chemistry , combinatorial chemistry , medicinal chemistry
Attachment of the Boc group to pyrrole nitrogen can now be achieved by a universally applicable method. Preparation of the N ‐Boc derivatives 1 from the corresponding pyrroles has been accomplished with Boc 2 O in presence of the strong acylating catalyst 4‐dimethylaminopyridine in CH 3 CN or CH 2 Cl 2 at room temperature. A wide variety of substituents R 1 —R 4 can be used.
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