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Ring Expansion of Benzothiete to 2,3‐Dihydrobenz[ d ]isothiazoles
Author(s) -
Kanakarajan Kuppusamy,
Meier Herbert
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198402441
Subject(s) - ring (chemistry) , dimer , saccharin , chemistry , tricyclic , stereochemistry , organic chemistry , medicine , endocrinology
The framework of saccharin and other artificial sweeteners is contained in the title compound 2 . The new route to this class of substances starts from the readily accessible benzothietes 1 . Compound 2 is formed via thermal ring‐opening of 1 ; intermediate formation of a tricyclic dimer of 1 can be ruled out.
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