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Total Synthesis of a Fortimicin Aglycone
Author(s) -
Schubert Jürgen,
Schwesinger Reinhard,
Prinzbach Horst
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198401671
Subject(s) - aglycone , total synthesis , aminoglycoside , stereochemistry , chemistry , antibiotics , aminocyclitol , combinatorial chemistry , glycoside , biochemistry
Novel broad band aminoglycoside antibiotics such as the fortimicins 2 contain cis ‐1,4‐(deoxy)inosadiamines as aglycones. With 1 , ROH, as starting material convenient syntheses of enantiomerically pure 3‐de‐ O ‐methylfortamine 3 , RH, of derivatives bearing protecting groups as well as of analogues were developed.