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Enzymatic Syntheses of Chiral Building Blocks from Prochiral meso ‐Substrates: Preparation of Methyl(hydrogen)‐1,2‐cycloalkanedicarboxylates
Author(s) -
Schneider Manfred,
Engel Norbert,
Hönicke Petra,
Heinemann Gerd,
Görisch Helmut
Publication year - 1984
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198400671
Subject(s) - enantioselective synthesis , hydrolysis , esterase , chemistry , enzyme , hydrogen , stereochemistry , enzymatic hydrolysis , organic chemistry , catalysis
Chiral cis ‐monoesters 2 have been obtained from prochiral meso‐diesters 1 of 1,2‐cycloalkanedicarboxylic acids by enantioselective hydrolysis with procine liver esterase. In most cases the enantioselectivity is high. R is, e.g., CMe 2 , (CH 2 ) 2 , or (CH 2 ) 4 .
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