Premium
Induction of Asymmetry by Amino Acids
Author(s) -
Drauz Karlheinz,
Kleeman Axel,
Martens Jürgen
Publication year - 1982
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198205841
Subject(s) - steric effects , enantiomer , amino acid , stereoselectivity , stereochemistry , chemistry , enantioselective synthesis , asymmetric induction , molecule , stereoisomerism , organic chemistry , biochemistry , catalysis
Since the stereoisomers of molecules with one or more asymmetric centers often exhibit different biological activities ( e.g. thalidomide, pheromones), stereoselective synthesis as a method of preparative chemistry is rapidly attaining importance. Of the numerous drugs prepared by total synthesis that contain at least one asymmetric center, only about 20% have so far been used in sterically pure form. Amino acids constitute the greatest “chiral pool” of compounds whose enantiomers can be obtained commercially in large amounts; they are gradually being used more and more frequently as auxiliary agents or educts in asymmetric syntheses.