A New Route to 6a‐Carbacyclins–Synthesis of a Stable, Biologically Potent Prostacyclin Analogue | Zendy

Skuballa Werner | Zendy; Vorbrüggen Helmut | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A New Route to 6a‐Carbacyclins–Synthesis of a Stable, Biologically Potent Prostacyclin Analogue

Author(s) -

Skuballa Werner,

Vorbrüggen Helmut

Publication year - 1981

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198110461

Subject(s) - prostacyclin , chemistry , stereochemistry , octane , biological activity , bicyclic molecule , lactone , vasodilation , platelet aggregation , derivative (finance) , platelet , pharmacology , biochemistry , biology , medicine , in vitro , organic chemistry , economics , financial economics

6a‐Carbacyclin (1) (X = CH 2 , R = CH(CH 3 )CH 2 CCCH 3 ), a potent vasodilator and inhibitor of blood‐platelet aggregation , exhibits the same activity‐profile and comparable efficacy as prostacyclin, but, in contrast to prostycyclin, is much more stable. It was prepared from the commercially available Corey lactone (2) (R 1 = H) via the bicyclo[3.3.0]octane derivative (3) .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research