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Cyclopropanation with Dimethylcarbene
Author(s) -
Fischer Peter,
Schaefer Gerhard
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198108631
Subject(s) - cyclopropanation , yield (engineering) , ether , diethyl ether , chemistry , organic chemistry , physics , catalysis , thermodynamics
The first preparatively useful entry to dimethylcarbene is the α‐elimination from 2,2‐di‐bromopropane with n ‐butyllithium in diethyl ether at −70°C without auxiliary bases. For example, hexamethylcyclopropane (1) can be prepared in this way in 46% yield.