Premium
Synthesis of Enantiomerically Pure ( R )‐ and ( S )‐α Hydroxyketones and Vicinal Diols; Asymmetric Nucleophilic Carbamoylation
Author(s) -
Enders Dieter,
Lotter Hermann
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198107951
Subject(s) - vicinal , diastereomer , enantiomer , chemistry , nucleophile , formamide , enantioselective synthesis , diol , organic chemistry , stereochemistry , catalysis
The combination of asymmetric CC‐coupling, chromatographic separation of the diastereomers, and their conversion into enantiomers permits the synthesis of enantiomerically pure ( R )‐ and ( S )‐α‐hydroxyketones and vicinal diols from ketones R 1 R 2 CO, the chiral formamide (1) , and CH 3 Li.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom