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An Expeditious and Efficient Entry into the Aphidicolin and Related Natural Products Ring Skeleton
Author(s) -
Nicolaou K. C.,
Zipkin Robert E.
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198107851
Subject(s) - aphidicolin , ring (chemistry) , antimitotic agent , skeleton (computer programming) , yield (engineering) , natural (archaeology) , chemistry , stereochemistry , combinatorial chemistry , computer science , biology , physics , organic chemistry , programming language , biochemistry , microbiology and biotechnology , dna synthesis , microtubule , tubulin , thermodynamics , paleontology , in vitro
The synthesis of the uniquely coupled ring system of aphidicolin (1) and similar natural products in a stereocontrolled manner can be achieved in a few steps in good overall yield starting from 5‐methoxy‐2‐indanone. (1) has potent antiviral and antimitotic properties.